diff --git a/gcc/ipa-modref.c b/gcc/ipa-modref.c
index df4612bbff9..8966f9fd2a4 100644
--- a/gcc/ipa-modref.c
+++ b/gcc/ipa-modref.c
@@ -724,6 +724,22 @@ get_modref_function_summary (cgraph_node *func)
   return r;
 }
 
+/* Get function summary for CALL if it exists, return NULL otherwise.
+   If INTERPOSED is non-NULL set it to true if call may be interposed.  */
+
+modref_summary *
+get_modref_function_summary (gcall *call, bool *interposed)
+{
+  tree callee = gimple_call_fndecl (call);
+  if (!callee)
+    return NULL;
+  struct cgraph_node *node = cgraph_node::get (callee);
+  if (!node)
+    return NULL;
+  if (interposed)
+    *interposed = !node->binds_to_current_def_p ();
+  return get_modref_function_summary (node);
+}
+
 namespace {
 
 /* Construct modref_access_node from REF.  */
diff --git a/gcc/ipa-modref.h b/gcc/ipa-modref.h
index 9e8a30fd80a..72e608864ce 100644
--- a/gcc/ipa-modref.h
+++ b/gcc/ipa-modref.h
@@ -50,6 +50,7 @@ struct GTY(()) modref_summary
 };
 
 modref_summary *get_modref_function_summary (cgraph_node *func);
+modref_summary *get_modref_function_summary (gcall *call, bool *interposed);
 void ipa_modref_c_finalize ();
 void ipa_merge_modref_summary_after_inlining (cgraph_edge *e);
 
diff --git a/gcc/testsuite/gcc.dg/tree-ssa/modref-dse-4.c b/gcc/testsuite/gcc.dg/tree-ssa/modref-dse-4.c
new file mode 100644
index 00000000000..81aa7dc587c
--- /dev/null
+++ b/gcc/testsuite/gcc.dg/tree-ssa/modref-dse-4.c
@@ -0,0 +1,26 @@
+/* { dg-do compile } */
+/* { dg-options "-O2 -fdump-tree-dse2-details"  } */
+struct a {int a,b,c;};
+__attribute__ ((noinline))
+void
+kill_me (struct a *a)
+{
+  a->a=0;
+  a->b=0;
+  a->c=0;
+}
+__attribute__ ((noinline))
+void
+my_pleasure (struct a *a)
+{
+  a->a=1;
+  a->c=2;
+}
+void
+set (struct a *a)
+{
+  kill_me (a);
+  my_pleasure (a);
+  a->b=1;
+}
+/* { dg-final { scan-tree-dump "Deleted dead store: kill_me" "dse2" } } */
diff --git a/gcc/tree-ssa-dse.c b/gcc/tree-ssa-dse.c
index ce0083a6dab..d2f54b0faad 100644
--- a/gcc/tree-ssa-dse.c
+++ b/gcc/tree-ssa-dse.c
@@ -209,6 +209,24 @@ normalize_ref (ao_ref *copy, ao_ref *ref)
   return true;
 }
 
+/* Update LIVE_BYTES tracking REF for write to WRITE:
+   Verify we have the same base memory address, the write
+   has a known size and overlaps with REF.  */
+static void
+clear_live_bytes_for_ref (sbitmap live_bytes, ao_ref *ref, ao_ref *write)
+{
+  HOST_WIDE_INT start, size;
+
+  if (valid_ao_ref_for_dse (write)
+      && operand_equal_p (write->base, ref->base, OEP_ADDRESS_OF)
+      && known_eq (write->size, write->max_size)
+      && normalize_ref (write, ref)
+      && (write->offset - ref->offset).is_constant (&start)
+      && write->size.is_constant (&size))
+    bitmap_clear_range (live_bytes, start / BITS_PER_UNIT,
+			size / BITS_PER_UNIT);
+}
+
 /* Clear any bytes written by STMT from the bitmap LIVE_BYTES.  The base
    address written by STMT must match the one found in REF, which must
    have its base address previously initialized.
@@ -220,20 +238,21 @@ static void
 clear_bytes_written_by (sbitmap live_bytes, gimple *stmt, ao_ref *ref)
 {
   ao_ref write;
+
+  if (gcall *call = dyn_cast <gcall *> (stmt))
+    {
+      bool interposed;
+      modref_summary *summary = get_modref_function_summary (call, &interposed);
+
+      if (summary && !interposed)
+	for (auto kill : summary->kills)
+	  if (kill.get_ao_ref (as_a <gcall *> (stmt), &write))
+	    clear_live_bytes_for_ref (live_bytes, ref, &write);
+    }
   if (!initialize_ao_ref_for_dse (stmt, &write))
     return;
 
-  /* Verify we have the same base memory address, the write
-     has a known size and overlaps with REF.  */
-  HOST_WIDE_INT start, size;
-  if (valid_ao_ref_for_dse (&write)
-      && operand_equal_p (write.base, ref->base, OEP_ADDRESS_OF)
-      && known_eq (write.size, write.max_size)
-      && normalize_ref (&write, ref)
-      && (write.offset - ref->offset).is_constant (&start)
-      && write.size.is_constant (&size))
-    bitmap_clear_range (live_bytes, start / BITS_PER_UNIT,
-			size / BITS_PER_UNIT);
+  clear_live_bytes_for_ref (live_bytes, ref, &write);
 }
 
 /* REF is a memory write.  Extract relevant information from it and
